منابع مشابه
Cooperative, ion-sensitive co-assembly of tripeptide hydrogels.
Peptide co-assembly is of interest for the development of functional supramolecular biomaterials. Herein, computational simulations were combined with experimental validation to aid the design and understanding of cooperative co-assembly of a structure-forming tripeptide (FFD) and a functional copper-binding tripeptide (GHK) leading to hydrogel formation in response to complexation with copper ...
متن کاملUnzipping the role of chirality in nanoscale self-assembly of tripeptide hydrogels.
Change of chirality is a useful tool to manipulate the aqueous self-assembly behaviour of uncapped, hydrophobic tripeptides. In contrast with other short peptides, these tripeptides form hydrogels at a physiological pH without the aid of organic solvents or end-capping groups (e.g. Fmoc). The novel hydrogel forming peptide (D)Leu-Phe-Phe ((D)LFF) and its epimer Leu-Phe-Phe (LFF) exemplify drama...
متن کاملAssembly of a Tripeptide and Anti-Inflammatory Drugs into Supramolecular Hydrogels for Sustained Release
Supramolecular hydrogels offer interesting opportunities for co-assembly with drugs towards sustained release over time, which could be achieved given that the drug participates in the hydrogel nanostructure, and it is not simply physically entrapped within the gel matrix. DLeu-Phe-Phe is an attractive building block of biomaterials in light of the peptide’s inherent biocompatibility and biodeg...
متن کاملTripeptide self-assembled hydrogels: unexpected twists of chirality.
Change of chirality of the first N-terminal amino acid of tripeptides VFF and FFV from l to d results in self-assembled hydrogels at physiological pH from non-assembling l-analogues. Interestingly, changing the chirality of F yields very different nanostructures; nanotapes are observed for (D)VFF, twisted fibers for (D)FFV.
متن کاملParamagnetic levitational assembly of hydrogels.
Figure 1 . (A) Schematic of hydrogel fabrication process. Hydrogel units were fabricated by photolithography. 20 μ L of gel precursor solution was Tissues and organs are composed of repeating functional units. [ 1–3,48 ] Among these repeating basic cellular structures are the hexagonal lobule in liver, the nephron in kidney, and the islets in pankreas. [ 4–6 ] Tissue engineering aims to mimic t...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2017
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c7cc04796g